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. 2011 Mar 1;1:201–210. doi: 10.7150/thno/v01p0201

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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(A-B) Representative coronal microPET images and radioactivity accumulation quantification of female athymic nude mice bearing U87MG tumors (treated with ⁹⁰Y-Abegrin^TM, ⁹⁰Y-IgG, Abegrin^TM, or saline) after i.v. injection of ¹⁸F-FDG (A) and ¹⁸F-FLT (B). (C) ¹⁸F-FDG imaging revealed a statistically significant reduction in both ⁹⁰Y-Abegrin^TM and Abegrin^TM signal intensity, suggesting reduced metabolic activity. (D) ¹⁸F-FLT imaging showed reduced tumor accumulation value in ⁹⁰Y-Abegrin^TM group, reflecting reduced DNA synthesis. Adapted with permission from ²⁹.