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. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Virology. 2011 Jan 14;411(2):229–236. doi: 10.1016/j.virol.2010.12.003

Figure 1.

Figure 1

Model of Influenza Virus Budding. A) The initiation of virus budding caused by clustering of HA (shown in red) and NA (shown in orange) in lipid raft domains. M1 (shown in purple) is seen binding to the cytoplasmic tails of HA and NA and serves as a docking site for the vRNPs (shown in yellow). B) Elongation of the budding virion caused by polymerization of the M1 protein, resulting in a polarized localization of the vRNPs. M2 (shown in blue) is recruited to the periphery of the budding virus though interactions with M1. C) Membrane scission caused by the insertion of the M2 amphipathic helix at the lipid phase boundary, altering membrane curvature at the neck of the budding virus and leading to release of the budding virus. D) Overview of the budding of influenza viruses, showing the coalescence of HA and NA containing lipid rafts (shown in yellow), the formation of a filamentous virion and membrane scission caused by M2 clustered at the neck of the budding virus.