Table 1. Genes overexpressed in malignant thyroid tumors identified by microarray analysis.
| Description | UG cluster | Gene symbol* | Parametric P value | Ratio † M/B | |
|---|---|---|---|---|---|
| High mobility group AT-hook 2, transcript variant 1 | ‡ | Hs.505924 | HMGA2 | 0.0001597 | 2.6 |
| Kallikrein 7 (chymotryptic, stratum corneum), transcript variant 1 | Hs.151254 | KLK7 | 0.0002012 | 2.5 | |
| Mannose receptor, C type 2 | Hs.7835 | MRC2 | <1e-07 | 2.5 | |
| Leucine-rich repeat kinase 2 | ‡ | Hs.187636 | LRRK2 | 3.46e-05 | 2.2 |
| Pleiomorphic adenoma gene 1 | ‡ | Hs. 14968 | PLAG1 | 0.0002047 | 2.2 |
| Cytochrome P450, family 1, subfamily B, polypeptide 1 | Hs.154654 | CYP1B1 | 0.0003485 | 2.0 | |
| Dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) | ‡ | Hs.368912 | DPP4 | 0.0006842 | 1.9 |
| Fibronectin type III domain containing 4 | Hs.27836 | FNDC4 | 3.30e-05 | 1.9 | |
| Pleckstrin homology-like domain, family A, member 2 | Hs.154036 | PHLDA2 | 6.00e-07 | 1.9 | |
| Cyclin A1 | Hs.417050 | CCNA1 | 8.08e-05 | 1.8 | |
| Cadherin 3, type 1, P-cadherin (placental) | ‡ | Hs.554598 | CDH3 | 1.10e-06 | 1.8 |
| Carcinoembryonic antigen-related cell adhesion molecule 6 (nonspecific cross-reacting antigen) | ‡ | Hs.466814 | CEACAM6 | 0.0001172 | 1.8 |
| Quiescin Q6 | Hs.518374 | QSCN6 | <1e-07 | 1.7 | |
| Collagen, type VII, a 1 (epidermolysis bullosa, dystrophic, dominant and recessive) | Hs.476218 | COL7A1 | 3.24e-05 | 1.7 | |
| Hypothetical protein MGC9712 | Hs.592174 | MGC9712 | 6.39e-05 | 1.7 | |
| Interleukin 1 receptor accessory protein, transcript variant 1 | Hs.478673 | IL1RAP | 9.68e-05 | 1.7 | |
| Laminin, β3, transcript variant 1 | Hs.497636 | LAMB3 | 0.0001874 | 1.7 | |
| Protease, serine, 3 (mesotrypsin) | ‡ | Hs.128013 | PRSS3 | 6.50e-06 | 1.7 |
| Low density lipoprotein receptor-related protein 4 | Hs.4930 | LRP4 | 0.0001359 | 1.6 | |
| Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | ‡ | Hs.124611 | SPOCK1 | 0.0001704 | 1.6 |
| Phosphodiesterase 5 A, cGMP-specific, transcript variant 3 | ‡ | Hs.370661 | PDE5A | 2.07e-05 | 1.6 |
| Hypothetical protein FLJ37078 | Hs.511025 | FLJ37078 | 0.000106 | 1.6 | |
| Fibrillin 3 | Hs.370362 | FBN3 | 0.0007772 | 1.6 | |
| DIRAS family, GTP-binding RAS-like 3 | Hs.194695 | DIRAS3 | 0.0001982 | 1.6 | |
| Protease, serine, 1 (trypsin 1) | Hs.511522 | PRSS1 | 0.0002246 | 1.6 | |
| Calcium/calmodulin-dependent protein kinase II inhibitor 1 | Hs.197922 | CAMK2N1 | 0.0005162 | 1.6 | |
| SNAP25-interacting protein | Hs.448872 | SNIP | 0.0001026 | 1.6 | |
| Potassium inwardly-rectifying channel, subfamily J, member 2 | Hs.1547 | KCNJ2 | 0.0001192 | 1.6 | |
| Stratifin | Hs.523718 | SFN | 3.23e-05 | 1.5 | |
| UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 | Hs.127407 | GALNT7 | 0.0002068 | 1.5 | |
| Transforming growth factor, α | Hs.170009 | TGFA | 0.0003326 | 1.5 | |
| BAI1-associated protein 3 | Hs.458427 | BAIAP3 | 4.13e-05 | 1.5 | |
| Potassium channel, subfamily K, member 15 | Hs.528664 | KCNK15 | 0.0001188 | 1.5 |
*
HUGO abbreviations used in Locus Link.
†
The ratio between Geo mean expression values of malignant to benign thyroid tumors (P ≤ 0.001).
‡
Genes validated by real-time RT-PCR.