Table 2. Genes underexpressed in malignant thyroid tumors identified by microarray analysis.
Description | UG cluster | Gene symbol* | Parametric P value | Ratio† M/B | |
---|---|---|---|---|---|
Recombination activating gene 2 | ‡ | Hs.159376 | RAG2 | 1.32e-05 | 0.41 |
Citrate lyase β-like, transcript variant 1 | Hs.130690 | CLYBL | 1.43e-05 | 0.44 | |
Nebulin | Hs.588655 | NEB | 0.0002811 | 0.53 | |
Tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | Hs.81791 | TNFRSF11B | 4.50e-06 | 0.54 | |
Guanine nucleotide binding protein (G protein), α inhibiting activity polypeptide 1 | Hs.134587 | GNAI1 | 4.33e-05 | 0.55 | |
Angiotensin II receptor, type 1, transcript variant 5 | ‡ | Hs.477887 | AGTR1 | 4.28e-05 | 0.56 |
Hepatic leukemia factor | Hs.196952 | HLF | 1.40e-06 | 0.57 | |
Solute carrier family 26, member 4 | Hs.571246 | SLC26A4 | 1.00e-07 | 0.58 | |
Metallothionein 1A (functional) | Hs.643532 | MT1A | 0.0004668 | 0.59 | |
Fatty acid binding protein 4, adipocyte | Hs.391561 | FABP4 | 4.38e-05 | 0.60 | |
Low density lipoprotein-related protein 1B (deleted in tumors) | Hs.470117 | LRP1B | 0.0003571 | 0.60 | |
Solute carrier family 4, sodium bicarbonate cotransporter, member 4 | Hs.5462 | SLC4A4 | 0.0002522 | 0.61 | |
PREDICTED: similar to programmed cell death 6 interacting protein, transcript variant 2 | Hs.597835 | LOC646278 | 0.0001965 | 0.61 | |
Mannosidase, a, class 1C, member 1 | Hs.197043 | MAN1C1 | 9.46e-05 | 0.61 | |
Kv channel interacting protein 3, calsenilin, transcript variant 2 | Hs.437376 | KCNIP3 | 1.12e-05 | 0.62 | |
DnaJ (Hsp40) homologue, subfamily B, member 9 | Hs.6790 | DNAJB9 | 5.10e-06 | 0.62 | |
Ubiquitin protein ligase E3 component n-recognin 1 | Hs.591121 | UBR1 | 0.000166 | 0.62 | |
Hydroxysteroid (17-β) dehydrogenase 6 | Hs.524513 | HSD17B6 | 0.0002557 | 0.62 | |
Solute carrier family 33 (acetyl-CoA transporter), member 1 | Hs.478031 | SLC33A1 | 2.49e-05 | 0.63 | |
Cadherin 16, KSP-cadherin | Hs.513660 | CDH16 | 0.0007068 | 0.63 | |
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 | Hs.176503 | TBC1D1 | 8.00e-07 | 0.63 | |
Solute carrier family 26, member 7, transcript variant 1 | Hs.354013 | SLC26A7 | 2.18e-05 | 0.63 | |
Chromosome 11 open reading frame 74 | Hs.406726 | C11orf74 | 1.40e-06 | 0.63 | |
Phospholipase A2 receptor 1, 180 kDa | Hs.410477 | PLA2R1 | 0.0001771 | 0.64 | |
Pituitary tumor-transforming 3 on chromosome 8. | PTTG3 | 5.00e-07 | 0.64 | ||
EGF-containing fibulin-like extracellular matrix protein 1, transcript variant 3 | Hs.76224 | EFEMP1 | 1.17e-05 | 0.64 | |
Zinc finger, matrin type 4 | Hs.591850 | ZMAT4 | 7.03e-05 | 0.64 | |
STEAP family member 3 | Hs.642719 | STEAP3 | 0.0002097 | 0.64 | |
Deiodinase, iodothyronine, type I, transcript variant 4 | Hs.251415 | DIO1 | 0.0007362 | 0.64 | |
v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homologue | Hs.479754 | KIT | 8.16e-05 | 0.65 | |
Thyroid peroxidase, transcript variant 5 | ‡ | Hs.467554 | TPO | 9.70e-06 | 0.65 |
Pituitary tumor-transforming 1 | Hs.350966 | PTTG1 | 6.00e-07 | 0.65 | |
Leucine-rich repeat LGI family, member 3 | Hs.33470 | LGI3 | 4.00e-05 | 0.65 | |
Transmembrane protein 38B | Hs.411925 | TMEM38B | 0.0001833 | 0.65 | |
SLIT and NTRK-like family, member 4 | Hs.272284 | SLITRK4 | 7.75e-05 | 0.65 | |
Von Hippel-Lindau binding protein 1 | Hs.436803 | VBP1 | 7.04e-05 | 0.65 | |
Collagen, type IX, α 3 | Hs.126248 | COL9A3 | 0.0009987 | 0.65 | |
Insulin receptor substrate 1 | Hs.471508 | IRS1 | 6.00e-06 | 0.66 | |
START domain containing 13, transcript variant γ | Hs.507704 | STARD13 | 0.0001052 | 0.66 | |
PREDICTED: similar to glycine cleavage system H protein, mitochondrial precursor, variant 1 | LOC654085 | 9.60e-06 | 0.66 | ||
Ribosomal protein S3A | Hs.356572 | RPS3A | 0.0004627 | 0.66 | |
SPARC-like 1 (mast9, hevin) | Hs.62886 | SPARCL1 | 7.61e-05 | 0.66 |
HUGO abbreviations used in Locus Link.
The ratio between Geo mean expression values of malignant to benign thyroid tumors (P ≤ 0.001).
Genes validated by real-time RT-PCR.