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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 Jan-Feb;3(1):86–99. doi: 10.1002/wnan.115

FIGURE 6.

FIGURE 6

Strategy for simultaneous molecular MRI of AnxCLIO-Cy5.5 and delayed gadolinium enhancement.15 The contrast produced by AnxCLIO-Cy5.5 is strongly modulated by the echo time (TE) used: At a TE of 1 ms at 9.4 T (a) the r1 and r2* effects of AnxCLIO-Cy5.5 balance each other, and the injured and uninjured areas of the myocardium are isointense. As the TE is increased to 2.5 ms (b) and 4 ms (c) signal hypointensity due to the accumulation of AnxCLIO-Cy5.5 in the injured myocardium becomes clearly visible (yellow arrows). A TE of 1 ms at 9.4 T thus produces a proton density-weighted image in the vicinity of AnxCLIO-Cy5.5, allowing delayed gadolinium enhancement to be detected (Reprinted with permission from Ref 15. Copyright 2009 the American Heart Association).