Skip to main content
. Author manuscript; available in PMC: 2011 May 3.
Published in final edited form as: AIDS. 2010 Sep 10;24(14):2161–2170. doi: 10.1097/QAD.0b013e32833dbc31

Fig. 4. Increased expression of cut homeobox 1 and transducin-like enhancer protein 4 in HIV-transgenic kidneys.

Fig. 4

(a–d) Paraffin sections of wild-type (a and c) and HIV-Tg (b and d) rat kidneys were labeled with antibodies directed against Cux1 (a and b) or TLE4 (c and d). Cux1 expression was minimal in both glomeruli and tubules in the wild-type kidney sections (arrows in a), but was markedly elevated in both glomerular and tubular cells in HIV-Tg rat kidneys (b). Similarly, TLE4 expression was increased in glomeruli from HIV-Tg kidneys (d) compared with the wild-type controls (c). (e–g) Western blots were performed on the kidney lysates for quantitative expression of Cux1 (e), TLE4 (f) and p27 (g). Although the expression of both Cux1 (e) and TLE4 (f) were significantly increased in the TG kidney lysates compared with the WT control, p27 was downregulated in HIV-Tg lysates (g). Cux1, cut homeobox 1; HIV-Tg, HIV-transgenic; TG, HIV-Tg; TLE4, transducin-like enhancer protein 4; WT, wild-type.

HHS Vulnerability Disclosure