Table 2.

Comparison of immunohistochemistry staining for activated Notch receptors from kidney biopsies of normal verses the HIV-associated nephropathy patients.

	Normal kidney	HIVAN	P
Notch1 IC	0.783 ± 1.66	2.885 ± 4.46	<0.001*
Notch2 IC	99.24 ± 49.9	95.66 ± 43.03	0.386
Notch3 IC	41.167 ± 15.93	76.33 ± 37.17	<0.0001**
Notch4 IC	0.128 ± 0.741	15.5 ± 13.85	<0.0001**

Kidney biopsy section obtained from the HIVAN patients (n = 3) or the patients with no HIVAN (normal) (n = 3) were labeled for the presence of intracellular domains of Notch1, 2, 3 and 4. Positive labeling in the nuclei was counted manually from at least 20 random fields from each section. Data are represented as mean ± SD. HIVAN, HIV-associated nephropathy; IC, intracellular.

^*P < 0.05 was considered statistically significant.

^**P < 0.001 was considered highly statistically significant.