Table I.
Correlation of miR-145 expression levels with p53 status and miR-145 methylation in tumor and adjacent normal tissues
| Samples | miR-145 expression | Met-T (%) | Met-N (%) | dMet (T-N) | p53 mutation |
| 1 | 0.224 | 98 | 60 | 38 | S241F |
| 2 | 0.087 | 78 | 60 | 18 | N288Y |
| 3 | 0.141 | 71 | 26 | 45 | C242S |
| 4 | 0.744 | 80 | 75 | 5 | R175P |
| 5 | 1.316 | 69 | 67 | 2 | — |
| 6 | 0.192 | 87 | 60 | 27 | Y236N |
| 7 | 0.103 | 93 | 58 | 35 | M246L |
| 8 | 0.694 | 88 | 64 | 24 | — |
| 9 | 0.130 | 87 | 83 | 4 | — |
| 10 | 0.938 | 86 | 81 | 5 | — |
| 11 | 1.038 | 76 | 71 | 5 | — |
| 12 | 0.913 | 93 | 82 | 11 | — |
| 13 | 0.276 | 86 | 62 | 24 | S240G |
| 14 | 0.191 | 83 | 79 | 4 | A119T |
| 15 | 0.061 | 83 | 60 | 23 | — |
| 16 | 0.407 | 77 | 69 | 8 | — |
| 17 | 0.375 | 74 | 58 | 16 | C242Y |
| 18 | 0.008 | 85 | 63 | 22 | — |
| 19 | 0.163 | 86 | 60 | 26 | Q104E |
| 20 | 0.326 | 77 | 73 | 4 | — |
| 21 | 0.658 | 89 | 76 | 13 | R273S |
Low miR-145 expression was arbitrarily defined as smaller than 0.75 (standardized by adjacent normal) and indicated in bold. Methylation (%) in tumor (T) and adjacent normal (N) was the average of percentages at six CpG sites. dMethylation was the difference between methylation in cancer and adjacent normal. Values >20 were considered to represent significantly higher methylation and shown in bold. p53 mutations are indicated with codon number and names of involved amino acids.