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. Author manuscript; available in PMC: 2011 May 3.
Published in final edited form as: Oncogene. 2009 Jul 6;28(38):3349–3359. doi: 10.1038/onc.2009.202

Figure 1.

Figure 1

Deletion of Stat3 in vivo renders mice resistant to Friend disease. (a) Wild-type BALB/c and Balb/c-Stat3fl/fl;Mx1Cre mice were injected with phosphate-buffered saline (PBS) or pI/pC followed by infection with Friend virus. Two weeks following infection, spleens were harvested and splenic weights are shown. N=3 mice for each experimental group. (b) Analysis of Stat3 phosphorylation and protein expression. Spleens were harvested on days 0 and 7 following infection and expression of phosphorylated Stat3 and total Stat3 was assessed by western blot analysis. (c) Hematoxylin and eosin (H&E) staining of spleens from wild-type or Stat3Δ/Δ mice 14 days postinfection with FVP. *P<0.05.