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The loss of an individual BH3 protein is not sufficient to prevent hyperoxia-induced mortality. Mice globally deficient in the proapoptotic BH3 proteins (A) Bim, (B) Puma, or (C) Noxa were exposed to hyperoxia for measurement of survival. Bim: n = 5 for wild-type and Bim−/−, P = 0.8. Puma: n = 5 for wild-type and Puma−/−, P = 0.87. Noxa: n = 21 for wild-type, n = 23 for Noxa−/−, P = 0.87.
