TABLE 4.

Meta-Analysis of Single-SNP Associations in the Caucasian Datasets

	All Caucasian Datasets Excluding Toronto Dataset								All Caucasian Datasets
SNP	Allele1	Allele2	Weight	Zscore	p	Direction	I2	p(Q)a	Allele1	Allele2	Weight	Zscore	p	Directiona	I2	p(Q)
1	Not genotyped in NIA-LOAD								Not genotyped in NIA-LOAD
2	c	g	3967	0.881	0.37	+++	0.22	0.92	c	g	4639	1.018	0.3	++++	0.23	0.92
3	Not polymorphic								Not polymorphic
4	a	g	3967	−2.769	0.005	− − −	0.34	0.9	a	g	4639	−1.75	0.08	− − −+	4.21	0.9
5	t	c	3967	2.693	0.007	+++	0.12	0.9	t	c	4639	1.618	0.1	+++−	3.12	0.9
6	Not genotyped in MIRAGE Caucasian								Not genotyped in MIRAGE
7	a	g	3967	−3.153	0.001	− − −	0.32	0.9	a	g	4639	−2.182	0.03	− − −+	6.14	0.9
8	t	c	3967	−3.334	0.0008	− − −	0.24	0.9	t	c	4639	−2.405	0.01	− − −+	5.27	0.9
9	t	c	3967	−2.895	0.003	− − −	5.23	0.7	t	c	4639	−1.909	0.05	− − −+	6.48	0.7
10	t	g	3967	−0.319	0.74	+− −	9.47	0.4	t	g	4639	−0.359	0.71	+333	8.84	0.4
11	a	g	3967	1.892	0.06	+++	7.86	0.5	a	g	4639	1.348	0.17	+++−	7.96	0.5
12	a	g	3967	0.15	0.88	−+ −	16.13	0.3	a	g	4639	−0.06	0.95	−+ − −	15.42	0.3
13	t	c	3967	2.168	0.03	+++	14.1	0.3	t	c	4639	1.784	0.07	+++−	14.14	0.3
14	t	c	3967	0.902	0.36	+− −	18.26	0.3	t	c	4639	1.047	0.29	+− −+	16.93	0.3
15	c	g	3967	0.999	0.31	++−	0.43	0.9	c	g	4639	0.806	0.42	++−	2.31	0.9
16	Not genotyped in MIRAGE Caucasian/Miami								Not genotyped in MIRAGE Caucasian/Miami

All p values of ≤0.05 are in bold. All p values that are close to statistical significance (0.05 ≤p ≤ 0.1) are in italics. SNPs that are associated with a changed risk for AD in at least 2 independent data sets are underlined.

^aHeterogeneity (Cochran’s Q) p-value.

χ² = chi square test statistic; AD = Alzheimer’s disease; SNP = single-nucleotide polymorphism.