Table 3. Genetic variants and risk of vitamin D insufficiency.

	< 75 nmol/L		< 50 nmol/L
	Odds ratio*	P-value	Odds ratio*	P-value
Individual variants
GC (rs2282679)	1.63 (1.53-1.73)	3.5 × 10-50	1.49 (1.40-1.59)	7.5 × 10-33
DHCR7 (rs7944926)	1.21 (1.14-1.29)	4.1 × 10-10	1.21 (1.14-1.29)	4.7 × 10-09
CYP2R1 (rs10741657)	1.21 (1.45-1.29)	9.4 × 10-11	1.06 (1.00-1.13)	0.06
Genotype score
Quartile 1	1.0 (Referent)		1.0 (Referent)
Quartile 2	1.29 (1.15-1.46)		1.10 (0.97-1.25)
Quartile 3	1.56 (1.39-1.75)		1.38 (1.22-1.57)
Quartile 4	2.47 (2.20-2.78)		1.92 (1.70-2.16)
P-for-trend	2.3 × 10-48		1.0 × 10-26

For individual variants, odds ratios are per copy of the “risk allele” with 95% confidence intervals shown in parentheses. All logistic regressions were adjusted for age, sex, body mass index, and season.