Figure 4. Growth inhibition of parasites.

GI₅₀ (µM) data for selected library members against cultured P. falciparum (W2 strain), T. brucei brucei, or T. cruzi parasites. Data points above the dotted line had no measurable GI₅₀ (i.e., GI₅₀>25 µM). Data points are colored and shaped by chemotype as described in Figure 2. The relative area of data points reflects cytotoxicity to mammalian cell lines (larger squares demoting increasing % growth inhibition relative to a 100% inhibition control). Cytotoxicity evaluations were performed in Jurkat cells for the T. brucei and P. falciparum actives (at 10 µM test compound) and in BESM cells for the T. cruzi actives (at 20 test µM compound).