Table 2. Selected anti-plasmodium lead compounds with associated biochemical and cell-based assay data.

				IC50 (µM)		Ki (µM)		GI50 (µM)	Cytotoxicity (% inhibition at 10 µM)
cmpd	R1	R2	R3	falcipain-2	falcipain-3	catL	catB	P. falc. W2	Jurkat cells
14a	furyl	furyl	—	0.020	0.029	0.076	16	1.5	<5%
14b	o-ClPh	H	—	0.0087	0.023	0.71	1.3	2.0	<5%
14c	H	p-MeOPh	—	0.018	0.025	0.35	4.2	2.7	<5%
14d	Cl	furyl	—	0.017	0.014	0.28	18	3.9	<5%
15a	—	—	CF3	0.050	0.015	0.15	54	3.5	<5%
15b	—	—	Ph	0.024	0.0052	0.11	90	>20	<5%