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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Nov 11;31(2):289–296. doi: 10.1161/ATVBAHA.110.217901

Figure 4. Leukocyte-endothelium interactions in mesenteric post-capillary venules.

Figure 4

Leukocyte rolling (A) and adhesion (B) were studied in all experimental groups of rats by brightfield intravital microscopy and expressed as the number of leukocytes per minute and the number of leukocytes per 100 µm vessel length, respectively. Calpain or PKC inhibition reduced leukocyte-endothelium interactions to a similar extent in the STZ-diabetic microcirculation. In contrast, the inactive PKC inhibitor, BIM-V, failed to attenuate leukocyte rolling and adhesion in STZ-diabetic rats. Bars represent mean ± SEM, and numbers at the base of the bars represent the number of rats studied in each group.