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Predicted Charge Distribution for Camptothecin Analogs as Lactones
| pH | Charge | CPT | Topotecan | SN-38 | Rubitecan | Karenitecin | Gimatecan | ACPT | BCPT | BACPT |
|---|---|---|---|---|---|---|---|---|---|---|
| 6.8 | −1 | |||||||||
| 0 | 99% | 12% | 92% | 100% | 94% | 99% | 96% | 95% | 83% | |
| +1 | 1% | 88% | 1% | 6% | 1% | 4% | 5% | 17% | ||
| 7.4 | −1 | 1% | 2% | |||||||
| 0 | 100% | 35% | 96% | 100% | 98% | 100% | 99% | 99% | 95% | |
| +1 | 63% | 2% | 2% | 1% | 1% | 5% |
