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Predicted Charge Distribution for Camptothecin Analogs as Carboxylates
| pH | Charge | CPT | Topotecan | SN-38 | Rubitecan | Karenitecin | Gimatecan | ACPT | BCPT | BACPT |
|---|---|---|---|---|---|---|---|---|---|---|
| 6.8 | −1 | 92% | 12% | 54% | 100% | 61% | 95% | 73% | 68% | 34% |
| 0 | 8% | 86% | 46% | 39% | 5% | 27% | 32% | 66% | ||
| +1 | 1% | |||||||||
| 7.4 | −2 | 1% | 1% | |||||||
| −1 | 99% | 36% | 81% | 100% | 86% | 99% | 92% | 90% | 67% | |
| 0 | 2% | 63% | 17% | 14% | 1% | 8% | 10% | 33% | ||
| +1 |
