Table 1.

Endogenous ligands reported to be transported by OATP1B1

Endogenous substrates	Ligand class	Test system	Measurement	Km (μmol/l)	References
Taurocholic acid	Bile acid	293c18 cells	Transport	33.8	[6]
		Xenopus oocytes	Transport	13.6	[10]
		HeLa cells	Transport		[11]
Dehydroepiandrosterone sulfate	Conjugated steroid	293c18 cells	Transport		[6]
		Xenopus oocytes	Transport		[10]
		HEK 293	Transport		[5]
Estradiol-17beta-glucuronide	Conjugated steroid	Xenopus oocytes	Transport		[10]
		HeLa cells	Transport	5.1	[11]
		HEK 293	Transport		[12]
		HEK 293	Transport		[5]
		CHO cells	Transport	5.4	[13]
Estrone-3-sulfate	Conjugated steroid	Xenopus oocytes	Transport		[10]
		HeLa cells	Transport	0.54	[11]
		CHO cells	Transport	2.4	[13]
Prostaglandin E2	Eicosanoid	Xenopus oocytes	Transport		[10]
		HEK 293	Transport		[12]
Thromboxane B2	Eicosanoid	Xenopus oocytes	Transport		[10]
Leukotriene C4	Eicosanoid	Xenopus oocytes	Transport		[10]
Leukotriene E4	Eicosanoid	Xenopus oocytes	Transport		[10]
Thyroxine (T4)	Thyroid hormones	Xenopus oocytes	Transport	3	[10]
		293c18 cells	Transport	3	[6]
Triiodothyronine (T3)	Thyroid hormones	Xenopus oocytes	Transport	2.7	[10]

Columns are, in order: endogenous substrate; ligand class; test system, that is, cell system for in-vitro experiment versus in-vivo experiment; experimental measurement; Km, where available, and finally, references. Several ligands were studied by different investigators and these data are listed in separate rows. Data organized by ligand class.