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. Author manuscript; available in PMC: 2011 May 3.
Published in final edited form as: Int J Hyperthermia. 2011 Jan 4;27(1):42–52. doi: 10.3109/02656736.2010.510495

Figure 4.

Figure 4

Fractionated radiation treatment enhancement by rational scheduling of mild temperature hyperthermia. B16F10 tumour volumes after hyperthermia, radiation or combination treatments (A). Tumour-bearing animals were treated with control (-■-), heat (-▼-, 41.5°C 60 min on days 7 and 8; indicated by arrowhead), radiation (-▲-, 5 Gy, day 8 and 9, indicated by diamond arrow tail), or combined (-◇-). Data are plotted as means ± SEM over time with third order polynomial line fitting. Efficacy determination of combination therapy of heat and fractionated radiation (B). The following formula was applied to determine efficacy [21]: the expected tumour growth inhibition from combination treatment (tumour growth inhibition by hyperthermia × tumour growth inhibition by radiation) / observed tumour growth inhibition. A ratio >1 indicates a synergistic (greater than additive) effect.