Table 3. Advantages and disadvantages of including fluoxetine versus amitriptyline in the Interagency Emergency Health Kit (IEHK).

	Advantages	Disadvantages
Fluoxetine	1. Generally safer [18]2. Slightly better adherence [26]3. Can also be used in adolescents [18]	1. Can increase anxiety, which already is common in emergencies [18]2. Substantially more expensive and less cost-effective in many countries [26]
Amitriptyline	1. Most available anti-depressant in low-income countries [12]2. Sedative effect (less tendency to also prescribe benzodiazepines)3. Also analgesic (relevant in emergencies involving mass casualties)	1. More difficult to prescribe: medical examination is important to avoid rare but serious side effects (cardiac events) [18]2. Lower tolerance in older people [18]