Table 2. Multivariable model for the effect of cART and baseline covariates on study outcomes.

Variable	Death (165,164 Person-Days, 49 Events)		Death, Default, Lost to Follow-Up (165,164 Person-Days, 81 Events)		Death, Hospitalization, Serious Opportunistic Infection (140,687 Person-Days, 102 Events)
	Hazard Ratio [95% CI]	p-Value	Hazard Ratio [95% CI]	p-Value	Hazard Ratio [95% CI]	p-Value
“On cART”	0.3 [0.1, 1.1]	0.06	0.3 [0.1, 0.6]	0.0005	0.4 [0.2, 0.8]	0.02
Weeks “on cART”a	1.0 [0.9, 1.0]	0.005	1.0 [0.9, 1.0]	0.009	1.0 [0.9, 1.0]	0.10
First CD4 cell count (per 20-cell increase, linear)	0.8 [0.7, 0.9]	0.002	0.9 [0.9, 1.0]	0.003	0.9 [0.8, 1.0]	<0.001
Interaction between “on cART” and value of first CD4 cell count≤350 cells/µl	1.2 [1.0, 1.4]	0.03	—b		1.1 [1.0, 1.2]	0.03
Missing a CD4 cell count at TB treatment start	0.6 [0.3, 1.4]	0.25	1.2 [0.6, 2.2]	0.62	0.9 [0.5, 1.6]	0.65
Weeks between TB treatment start and first CD4 cell count≤350 cells/µl, if positivea	1.0 [1.0, 1.1]	0.55	1.0 [1.0, 1.1]	0.57	1.0 [0.9, 1.0]	0.48
Age≥43 y (75th percentile)	1.7 [0.9, 3.4]	0.12	1.1 [0.6, 2.0]	0.69	1.5 [0.9, 2.4]	0.10
Female gender	1.6 [0.8, 3.2]	0.20	1.1 [0.6, 1.8]	0.84	1.3 [0.8, 2.0]	0.32
Rural treatment site	1.4 [0. 7, 3.0]	0.36	0.9 [0.5, 1.6]	0.71	0.8 [0.4, 1.3]	0.32
In-patient at health facility at TB start	2.1 [1.1, 4.3]	0.04	1.4 [0.9, 2.5]	0.17	1.8 [1.1, 2.8]	0.02

Estimates are adjusted for all other variables in model and follow-up day, most recent CD4 cell count, and current hospitalization.

^aDays “on cART” and days to first CD4 cell count≤350 cells/µl transformed to the week scale.

^bThe interaction between “on cART” and value of first CD4 cell count≤350 cells/µl was not statistically significant for the combined endpoint of death, default, and lost to follow-up and was therefore not included in this multivariable model.