Table 5.
Age-standardized incidence rates and counts of adult (age ≥20 years) brain and other nervous system tumors including lymphomas by major histological groupings, sex, and behavior (nonmalignant, malignant), North American Association of Central Cancer Registries (NAACCR) combined, 2004–2007*
| Histological group† | Malignant, benign and borderline malignancy |
Malignant | Benign and borderline malignancy‡ | Percent malignant | ||||||
| Men |
Women |
Men and women |
||||||||
| Rate§ | Count | Rate§ | Count | Rate§ | Count | Median age | Count | Count | ||
| Brain and other nervous system | 22.37 | 83 281 | 26.55 | 115 508 | 24.55 | 198 789 | 60.0 | 66 968 | 131 821 | 33.7 |
| Tumors of neuroepithelial tissue | 9.38 | 35 275 | 6.47 | 27 813 | 7.81 | 63 088 | 59.0 | 59 888 | 3200 | 94.9 |
| Pilocytic astrocytoma | 0.14 | 550 | 0.13 | 534 | 0.14 | 1084 | 34.0 | 1084 | 0 | 100.0 |
| Diffuse and anaplastic astrocytoma‖ | 1.44 | 5433 | 1.04 | 4334 | 1.22 | 9767 | 53.0 | 9767 | 0 | 100.0 |
| Glioblastoma | 5.54 | 20 592 | 3.51 | 15 597 | 4.43 | 36 189 | 64.0 | 36 189 | 0 | 100.0 |
| Oligodendroglioma and anaplastic oligodendroglioma | 0.60 | 2338 | 0.47 | 1870 | 0.53 | 4208 | 45.0 | 4208 | 0 | 100.0 |
| Mixed glioma | 0.32 | 1227 | 0.22 | 866 | 0.27 | 2093 | 42.0 | 2093 | 0 | 100.0 |
| Glioma malignant, NOS | 0.44 | 1629 | 0.34 | 1478 | 0.39 | 3107 | 61.0 | 3107 | 0 | 100.0 |
| Embryonal/primitive/medulloblastoma | 0.09 | 353 | 0.07 | 274 | 0.08 | 627 | 33.0 | 625 | †† | 99.7 |
| All other tumors of neuroepithelial tissue¶ | 0.81 | 3153 | 0.70 | 2860 | 0.75 | 6013 | 45.0 | 2815 | 3198 | 46.8 |
| Tumors of cranial and spinal nerves | 2.25 | 8749 | 2.24 | 9498 | 2.24 | 18 247 | 54.0 | 190 | 18 057 | 1.0 |
| Nerve sheath | 2.25 | 8747 | 2.24 | 9495 | 2.24 | 18 242 | 54.0 | 190 | 18 052 | 1.0 |
| Acoustic neuromas | 1.45 | 5618 | 1.46 | 6240 | 1.45 | 11 858 | 55.0 | 32 | 11 826 | 0.3 |
| All other nerve sheath | 0.80 | 3129 | 0.77 | 3255 | 0.79 | 6384 | 53.0 | 158 | 6226 | 2.5 |
| Tumors of meninges | 5.79 | 20 907 | 12.67 | 56 339 | 9.50 | 77 246 | 65.0 | 1787 | 75 459 | 2.3 |
| Meningioma | 5.46 | 19 632 | 12.42 | 55 309 | 9.21 | 74 941 | 65.0 | 1577 | 73 364 | 2.1 |
| All other tumors of meninges# | 0.33 | 1275 | 0.25 | 1030 | 0.29 | 2305 | 49.0 | 210 | 2095 | 9.1 |
| Germ cell tumors and cysts | 0.06 | 235 | 0.02 | 97 | 0.04 | 332 | 28.0 | 229 | 103 | 69.0 |
| Tumors of sellar region | 3.46 | 13 098 | 3.75 | 15 398 | 3.56 | 28 496 | 52.0 | 117 | 28 379 | 0.4 |
| All other brain** | 1.42 | 5017 | 1.39 | 6363 | 1.40 | 11 380 | 69.0 | 4757 | 6623 | 41.8 |
| Lymphomas and hematopoietic neoplasms of the brain and ONS | 0.75 | 2764 | 0.54 | 2357 | 0.64 | 5121 | 64.0 | 5118 | †† | 99.9 |
NOS = not otherwise specified; ONS = other nervous system. Source: NAACCR Combined—National Program of Cancer Registries and Surveillance, Epidemiology, and End Results Program areas reported by NAACCR as meeting high-quality incidence data standards for 2003–2007 (46 states): Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nebraska, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, Wyoming. The table excludes cancer cases that were identified as having invalid site/histology combinations.
The site grouping “Brain and ONS” includes cancer cases with primary sites C70.0–C72.9 and C75.1–C75.3. The category “Lymphomas and hematopoietic neoplasms of the brain and ONS” refers to those lymphomas and hematopoietic neoplasms with a primary site of C70.0–C72.9, C75.1–C75.3 as defined in Central Brain Tumor Registry of the United States (CBTRUS) (2010). CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2004–2006.
Benign and borderline cancer cases for the following tumors were recoded as malignant: diffuse astrocytoma, anaplastic astrocytoma, glioblastoma, oligodendroglioma, anaplastic oligodendroglioma, ependymoma/anaplastic ependymoma, mixed glioma, glioma malignant, NOS.
Incidence rates are per 100 000 persons and were age standardized to the 2000 US standard population (19 age groups: <1, 1–4, 5–9, 10–14, … , 80–84, ≥85 years, Census P25–1130).
Diffuse astrocytoma (as defined by World Health Organization 2007) includes the following histological groups: protoplasmic and fibrillary astrocytoma, astrocytoma NOS, and gemistocytic astrocytomas (9411).
All other tumors of neuroepithelial tissue includes the following histological groups: unique astrocytoma variants, ependymoma variants, choroid plexus, neuroepithelial, and pineal parenchymal, neuronal/glial, neuronal and mixed.
All other tumors of meninges includes the following histological groups: other mesenchymal, hemangioblastoma.
All other brain includes the following histological groups: chordoma/chondrosarcoma, hemangioma, unspecified neoplasms, and all other histologies which could not be classified above.
Counts less than six are not displayed except when equal to zero.