Figure 6. Analysis of signalogs as drug target candidates.

a) Numbers of membrane proteins (M), enzymes (E), proteins with a kinase domain (K), and disease-related proteins (D) among signalog proteins (control: all proteins of the SignaLink database). b) Numbers of signalogs in the groups defined by the number of key properties out of the listed 4 (M, E, K, and D). For each group, the number of drug targets is shown separately. The names of the most promising drug target candidate proteins and 2 already known drug targets (both do have all 4 key properties) are listed. Table S2 lists all human signalog proteins and their drug target relevance scores.