Table 4. Orthodisease proteins among signalogs in D. melanogaster.
| Signalog | Predicted pathway | Human ortholog(s) | Disease related to the human ortholog |
| S6kII | EGF/MAPK | Ribosomal protein S6 kinase alpha-3 (RPS6KA3) | Coffin-Lowry syndrome |
| Rab23 | Hedgehog | Ras-related protein 23 (RAB23) | Carpenter syndrome |
| smt3 | TGF-β | Small ubiquitin-related modifier 4 (SUMO4) | Diabetes mellitus |
| bonus | TGF-β | Transcription intermediary factor 1 (TRIM24), E3 ubiquitin-protein ligase (TRIM33) | Thyroid carcinoma |
| lkb1 | EGF/MAPK, WNT | Serine/threonine-protein kinase 11 (STK11) | Peutz-Jeghers syndrome, Testicular tumors |
| Pkc53E | EGF/MAPK | Protein kinase C gamma (PKCG) | Spinocerebellar ataxia |
| tws | EGF/MAPK | Serine/threonine-protein phosphatase 2A (PPP2R2B) | Spinocerebellar ataxia |
| Ror | TGF-β, WNT | Tyrosine-protein kinase transmembrane receptor (ROR2) | Brachydactyly, Robinow syndrome |
| ELP1 | EGF/MAPK | Elongator complex protein 1 (IKBKAP) | Hereditary sensory neuropathy |
The D. melanogaster signalog proteins that have one or more human ortholog(s) related to a disease (orthodisease proteins). The list of disease-related human proteins was downloaded from the Orthodisease database [46].