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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Clin Cancer Res. 2011 Jan 17;17(9):2934–2946. doi: 10.1158/1078-0432.CCR-10-1803

Figure 2.

Figure 2

A. Clinical, genomic and clinicogenomic RFS models of training cohort (stage I-III patients). The clinical model is: Cox score = Histology (-16.12716 × Squamous - 1.03510 × other) + 0.95865 × pStage + 0.22791 × Gender + Race (-0.57444 × African American - 0.95745 × Undetermined); the genomic model is: Cox score = -713.79613 × DBN1 -1090 × CCND2 + 668.28496 × CACNB3 + 383.51066 × PP591; and the clinicogenomic model is: Cox score = -1218 × DBN1 - 2072 × CCND2 + 1710 × CACNB3 + 507.39229 × PP591 + Histology (-14.22074 × Squamous - 2.78616 × other) + 0.60136 × pStage + 1.40561 × gender + Race (-3.16002 × Black - 3.44106 × Undetermined). The cutoffs (i.e. median Cox scores) for the clinical, genomic and clinicogenomic models were 1.18655, -30.8891 and -45.2830, respectively. Time to recurrence is expressed in months; number of patients: 27.

B. Genomic and clinicogenomic RFS models of validation cohort (stage I-III patients). The genomic model is: Cox score = 0.38040 × DBN1 + 0.30160 × CACNB3 - 0.93964 × CCND2 + 0.28898 × FLAD1; the clinicogenomic model is: Cox score = pT stage (0.58862 × T2+2.19489 × T3+0.31153 × T4) + pN stage (0.75430 × N1+1.24674 × N2) + 0.56392 × DBN1 + 0.43517 × CACNB3 - 0.61023 × CCND2 + 0.39543 × FLAD1. The median Cox scores for the genomic and clinicogenomic models were 3.66 and 7.43, respectively. Time to recurrence is expressed in months; number of patients: 138. The clinical model for this set of patients has been previously published (11).

C. Genomic and clinicogenomic RFS models of validation cohort (stage I-II patients). The genomic model is: Cox score = 0.37488 × DBN1 + 0.47831 × CACNB3 - 0.98259 × CCND2 + 0.33511 × FLAD1; the clinicogenomic model is: Cox score = pT stage (0.82325 × T2 + 2.78736 × T3) + 1.02786 × pN stage + 0.54254 × DBN1 + 0.46196 × CACNB3 - 0.99139 × CCND2 + 0.36875 × FLAD1. Time to recurrence is expressed in months; number of patients: 112.