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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Clin Cancer Res. 2011 Mar 17;17(9):2874–2884. doi: 10.1158/1078-0432.CCR-10-2334

Figure 4. eIF4E is overexpressed in primary and metastatic lesions of patients with breast cancer.

Figure 4

(A–B) Box plots showing elevated eIF4E mRNA levels in (A) primary breast tumors and (B) primary breast tumors and breast cancer metastasis over normal breast tissue. (*) denotes significance by t-test (p<0.05). (C) mRNA levels in malignant and normal skin were assessed by qPCR and results were normalized to RPL13a. For each patient, normal skin was used as a calibrator (RQ=1). (D) Immunohistochemistry shows strong eIF4E staining in malignant skin.