Table 5.
Effects of HPLC sub-fractions of extracts from Ankistrodesmus convolutus and Synechococcus elongatus against the release of EBV in Akata, B95-8, and P3HR-1 cells based on the amount of cell-free EBV DNA detected by real-time PCR
| Cell line | HPLC sub-fraction | IC50 (μg/ml) | EC50 (μg/ml) | Therapeutic index |
| Akata | Ankistrodesmus convolutus | |||
| ACF2’a | >20 | 2.8±0.9 | >7.0 | |
| ACF2’b | >20 | >20 | ND | |
| ACF2’c | 7.9±0.9 | 3.5±0.7 | 2.3 | |
| ACF2’d | 4.0±1.3 | 1.6±0.2 | 2.6 | |
| ACF2’e | >20 | 1.7±0.1 | >12.1 | |
| ACF2’f | >20 | 2.2±0.5 | >9.0 | |
| ACF3’a | >20 | >20 | ND | |
| ACF3’b | >20 | >20 | ND | |
| ACF3’c | >20 | >20 | ND | |
| ACF3’d | >20 | >20 | ND | |
| ACF3’e | >20 | >20 | ND | |
| ACF3’f | >20 | >20 | ND | |
| ACF3’g | >20 | >20 | ND | |
| B95-8 | Ankistrodesmus convolutus | |||
| ACF1’a | 1.4±0.1 | 11.3±1.7 | 0.1 | |
| ACF1’b | >20 | 4.1±0.3 | >4.9 | |
| ACF1’c | 16.0±1.1 | >20 | <0.8 | |
| ACF1’d | >20 | >20 | ND | |
| ACF1’e | 13.0±1.4 | >20 | <0.7 | |
| ACF1’f | 9.8±2.6 | >20 | <0.5 | |
| ACF1’g | >20 | >20 | ND | |
| Synechococcus elongatus | ||||
| SEF3’a | >20 | >20 | ND | |
| SEF3’b | 1.4±0.1 | >20 | <0.1 | |
| SEF3’c | >20 | >20 | ND | |
| SEF3’d | 1.7±0.1 | >20 | <0.9 | |
| SEF3’e | >20 | >20 | ND | |
| P3HR-1 | Synechococcus elongatus | |||
| SEF1’a | >20 | 1.4±0.4 | >14.5 | |
| SEF1’b | >20 | >20 | ND | |
| SEF1’c | >20 | 1.5±0.2 | >13.1 | |
| SEF1’d | >20 | 1.4±0.1 | >14.0 | |
| SEF1’e | >20 | >20 | ND | |
| SEF3’a | >20 | 2.1±1.4 | >9.6 | |
| SEF3’b | >20 | >20 | ND | |
| SEF3’c | >20 | 4.2±0.2 | >4.8 | |
| SEF3’d | >20 | >20 | ND | |
| SEF3’e | >20 | >20 | ND | |