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. 2011 May;163(2):299–312. doi: 10.1111/j.1476-5381.2011.01208.x

Figure 4.

Figure 4

Suppression of HIF activity blocks dexrazoxane (DRZ)-mediated cardioprotection. (A) H9c2 cells were transfected with the expression vector ΔARNT or an empty vector (ev) and treated as indicated in Figure 3A. Viability was evaluated by means of the MTT assay. (B) H9c2 cells were transfected and treated as described for panel A, and apoptosis was evaluated by measuring caspase-3 activity. Mean values ± SD. *P < 0.001; ***P < 0.01; n = 5. MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.