Figure 6.

Acute N,N-decane-1,10-diyl-bis-3-picolinium diiodide (bPiDI) preferentially reduces nicotine self-administration relative to food-maintained responding. (A) Effect of bPiDI (1.94–5.83 µmol·kg⁻¹, s.c.) on mean (±SEM) number of nicotine (0.03 mg·kg⁻¹·infusion⁻¹) infusions earned (n = 8 rats) (*P < 0.05 vs. saline; S). (B) Effect of bPiDI (1.94–5.83 µmol·kg⁻¹, s.c.) on mean (±SEM) number of food pellets earned in drug-naïve rats (n = 6, open symbols) or rats (n = 6, filled symbols) that were treated with nicotine (0.4 mg·kg⁻¹, s.c.) for 10 days prior to operant training (*P < 0.05 vs. saline; S). (C) Effects of acute bPiDI (1.94–5.83 µmol·kg⁻¹, s.c.) on nicotine self-administration or food-maintained responding (food-maintained responding data represent the group average of drug-naïve and nicotine-treated rats presented in panel B) expressed as % saline control values. (# P < 0.05 vs. the effect of bPiDI on food-maintained responding).