Figure 7.

With repeated administration N,N-decane-1,10-diyl-bis-3-picolinium diiodide (bPiDI) reduces nicotine self-administration but not food-maintained responding. (A) Effect of bPiDI (1.94–5.83 µmol·kg⁻¹, s.c.; a single dose of bPiDI was given to each group) given once daily for 7 days on nicotine self-administration to rats (n = 7–8 per dose group) following three consecutive baseline sessions (‘B1’–‘B3’) and followed by three additional saline pretreatment sessions (‘S1’–‘S3’). (B) Effect of bPiDI (1.94–5.83 µmol·kg⁻¹, s.c.) on food-maintained responding given repeatedly for 7 days to rats (n = 6 per dose group) following three consecutive baseline sessions (‘B1’–‘B3’) and followed by 3 additional saline pretreatment sessions (‘S1’–‘S3’). (*P < 0.05 vs. saline).