Figure 5.

Effects of acute oral administration of JNJ-40418677 on Aβ levels in non-transgenic mouse brain as measured with differential elisa s. Mean (+SEM) brain Aβ levels after drug treatment are expressed as percentage of Aβ levels in brain of vehicle-treated mice. Mean (+SEM) brain JNJ-40418677 concentrations after drug treatment are expressed in µM. (A) Effect of JNJ-40418677 treatment on Aβtotal (left) and Aβ42 (right) levels in non-transgenic mouse brain 4 h after a single oral dose of 10, 30, 100 or 300 mg·kg⁻¹ (n = 6 mice per data point). Brain Aβtotal levels were not affected at any dose, while Aβ42 levels were dose-dependently reduced. (B) Brain levels of JNJ-40418677 (top left) and effect of JNJ-40418677 treatment on Aβtotal (top right), Aβ42 (bottom left) and Aβ38 (bottom right) levels in non-transgenic mouse brain at different time points after a single oral dose of 30 mg·kg⁻¹ (n = 6 mice per data point). Brain Aβ42 levels were significantly reduced compared with vehicle-treated mice, total Aβ levels were not affected and Aβ38 levels were significantly increased at time points between 2 and 24 h. *P < 0.05, **P < 0.01, ***P < 0.001 versus vehicle.