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Mean plasma and brain concentrations of JNJ-40418677 after administration of JNJ-40418677 via medicated diet to Tg2576 mice from 6 to 13 months of age
| Dosing schedule (mg·kg−1·day−1 JNJ-40418677) | Plasma concentration (µM) | Brain concentration (µM) |
|---|---|---|
| 20 | 0.38 ± 0.02 | 0.42 ± 0.02 |
| 60 | 2.7 ± 0.4 | 2.4 ± 0.3 |
| 120 | 13 ± 1 | 12 ± 1 |
Data are expressed as mean ± SEM (µM).
