Figure 9.

Time courses for the effects of exenatide, PB-105 (ExC39) and PB-106 (ExC39PEG20kDa) on random blood glucose levels expressed as fall in magnitude (A) and areas above curves (AACs, B) in streptozotocin (STZ)-induced diabetic mice. These mice developed diabetes with initial random blood sugar ranging from 16.7 to 44.4 mmol·L⁻¹ 3 days after s.c. injection of STZ (120 mg·kg⁻¹). Data are presented as means ± SEM; n = 7–11 in each group. *Denotes statistically significant difference compared with either exenatide group or PB-105 group (P < 0.05 by anova followed by Student-Newman-Keuls test).