Figure 5.

Effects of metformin on aortic pVASP expression. To examine NO–cGMP signal activation, total vasodilator-stimulated phosphoprotein (VASP) and phosphorylated (Ser²³⁹) VASP (pVASP) expression were assessed. Aortic lysates were analysed by SDS-PAGE. (A) Representative Western blot analyses of total VASP and pVASP expression in aortas of the different groups of arteries. (B) Averaged densitometric data for pVASP/total VASP ratio. Densitometry data are presented as mean ± SE. **P < 0.01, ***P < 0.001 versus Wistar group; §P < 0.05 versus GK control group; φφφP < 0.001 versus GK + AD group.