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Effects of metformin on aortic CCL2 accumulation in Wistar and diabetic GK rats fed with normal and AD diet. Representative aortic sections demonstrating increased CCL2 staining in the diabetic and GK + AD aortas. Panel presents aorta from control Wistar (A), diabetic GK (B), diabetic GK fed with AD diet (C), Wistar treated with metformin (D), diabetic GK treated with metformin (E) and diabetic GK + AD treated with metformin (F) rats.
