Table 1.

Body weight, and plasma lipid levels in 6 months old nondiabetic Wistar and diabetic Goto-Kakizaki (GK) rats and in GK rats fed with atherogenic diet (AD) with (W + M; GK + M; GK + M + AD) or without metformin treatment (W; GK; GK + AD)

	Wistar	W + M	GK control	GK + M	GK + AD	GK + AD + M
Body weight (g)	403.9 ± 6.9	439.6 ± 7.4	312.7 ± 5.8a	351 ± 8.9	387.3 ± 4.3b	383.6 ± 10.6b
Total cholesterol (mM)	1.82 ± 0.04	2.46 ± 0.17c	2.3 ± 0.05c	2.6 ± 0.03a	2.6 ± 0.14a	2.79 ± 0.08a,b
Non-HDL cholesterol (mM)	0.7 ± 0.04	1.1 ± 0.05	0.71 ± 0.03	0.99 ± 0.02	1.29 ± 0.12a,b	1.5 ± 0.07a,b
Triglycerides (mM)	1.23 ± 0.08	1.24 ± 0.1	1.69 ± 0.13	0.6 ± 0.02d	2.52 ± 0.23a,d	2.99 ± 0.13a,b
FFA (mM)	0.71 ± 0.08	0.69 ± 0.05	0.79 ± 0.04	0.53 ± 0.02	1.13 ± 0.04a,b	0.77 ± 0.05e

Data are expressed as mean ± SE (n = 6–16 animals in each group).

^aP < 0.001 versus Wistar rats.

^bP < 0.001 versus GK control group.

^cP < 0.01 versus Wistar rats.

^dP < 0.01 versus GK control group.

^eP < 0.001 versus GK + AD group.