Table 2.
Maximal relaxation responses (%) and pEC50 (-logEC50) in isolated aorta arteries of 6 month old variously treated spontaneously diabetic Goto-Kakizaki (GK) rats and age-matched nondiabetic Wistar (W) rats
| Wistar | W + M | GK control | GK + M | GK + AD | GK + AD + M | |
|---|---|---|---|---|---|---|
| Ach | ||||||
| pEC50 | 6.87 ± 0.04 | 6.88 ± 0.02 | 6.94 ± 0.09 | 6.94 ± 0.05 | 5.02 ± 0.14a,b | 6.6 ± 0.17c |
| Maximal relaxation (%) | 98.9 ± 4.8 | 99.9 ± 3.8 | 72 ± 2.1a | 98.8 ± 3.9b | 58 ± 1.8a,b | 99.7 ± 4.2b,c |
| SNP | ||||||
| pEC50 | 6.20 ± 0.04 | 6.27 ± 0.3 | 6.43 ± 0.04 | 6.51 ± 0.03 | 5.42 ± 0.03a,b | 5.93 ± 0.11b,c |
| Maximal relaxation (%) | 99.95 ± 0.11 | 99.75 ± 0.2 | 99.5 ± 0.12 | 99.3 ± 0.3 | 99.41 ± 0.4 | 99.9 ± 0.12 |
Data are expressed as mean ± SE (n = 6–16 animals in each group). pEC50 values are presented as the negative logarithm (–logEC50) of concentration of the agonist.
a
P < 0.001 versus Wistar rats.
b
P < 0.001 versus GK control group.
c
P < 0.001 versus GK + AD group.
d
P < 0.05 versus GK control group.