Table 3.
Incidence of Coronary Heart Disease by Presence or Absence of Insulin Resistance at Lower or Higher Values of Plasma HDL-C or Triglycerides.
| Groups | IR | HDL-C | HR (95% CI) Age-adjusted | P-value | HR (95% CI) Multi-adjusted | P-value |
|---|---|---|---|---|---|---|
| All Participants | yes | < median | 3.60 (2.32, 5.59) | <0.001 | 2.83 (1.70, 4.70) | <0.001 |
| yes | ≥ median | 1.73 (0.89, 3.38) | 0.11 | 1.46 (0.73, 2.91) | 0.29 | |
| no | < median | 1.56 (0.96 2.53) | 0.08 | 1.24 (0.74, 2.07) | 0.42 | |
| Men | yes | < median | 2.82 (1.64, 4.84) | <0.001 | 2.29 (1.24, 4.26) | 0.009 |
| yes | ≥ median | 2.03 (1.01, 4.09) | 0.048 | 1.73 (0.82, 3.65) | 0.15 | |
| no | < median | 1.32 (0.70, 2.46) | 0.39 | 1.09 (0.56, 2.10) | 0.81 | |
| Women | yes | < median | 5.88 (2.75,12.57) | <0.001 | 5.32 (2.08, 13.60) | <0.001 |
| yes | ≥ median | 0 (0, 0) | 0.98 | 0 (0, 0) | 0.99 | |
| no | < median | 2.15 (0.97, 4.79) | 0.06 | 1.88 (0.78, 4.49) | 0.16 | |
|
| ||||||
| Groups | IR | Triglycerides | HR (95% CI) Age-adjusted | P-value | HR (95% CI) Multi-adjusted | P-value |
|
| ||||||
| All Participants | yes | ≥ median | 3.01 (1.94, 4.66) | <0.001 | 2.50 (1.52, 4.11) | <0.001 |
| yes | < median | 1.75 (0.89, 3.47) | 0.11 | 1.60 (0.79, 3.25) | 0.19 | |
| no | ≥ median | 1.18 (0.72,1.92) | 0.51 | 0.96 (0.58, 1.57) | 0.86 | |
| Men | yes | ≥ median | 2.62 (1.55, 4.42) | <0.001 | 2.30 (1.27, 4.15) | 0.006 |
| yes | < median | 1.50 (0.67, 3.33) | 0.32 | 1.35 (0.58, 3.12) | 0.48 | |
| no | ≥ median | 1.02 (0.54, 1.91) | 0.96 | 0.84 (0.44, 1.60) | 0.59 | |
| Women | yes | ≥ median | 3.91 (1.78, 8.58) | <0.001 | 3.08 (1.23, 7.75) | 0.02 |
| yes | < median | 2.37 (0.65, 8.62) | 0.19 | 2.44 (0.64, 9.37) | 0.19 | |
| no | ≥ median | 1.39 (0.62, 3.10) | 0.43 | 1.05 (0.45, 2.45) | 0.91 | |
Abbreviations: CI, confidence interval; HDL-C, high-density lipoprotein cholesterol; HR, hazard ratio; IR, insulin resistance
Median values of HDL-C are 49 mg/dL for all subjects; 42 mg/dL for men; and 56 mg/dL for women. Median values of triglycerides are 112 mg/dL for all subjects; 121 mg/dL for men; and 108 mg/dL for women.
Multivariable-adjusted models were adjusted for age, sex, systolic blood pressure, waist circumference, active smoking, alcohol consumption, treatment of hypertension, hormone replacement therapy, and for non-HDL-C with HDL-C as the variable of interest and for non-triglyceride-related cholesterol with triglycerides as the variable of interest.