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. 2010 Jun 16;10:294. doi: 10.1186/1471-2407-10-294

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Copyright ©2010 McCready et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Extracellular hsp90α assists in the conversion of plasminogen to plasmin. (a) HT-1080 fibrosarcoma cells were treated with either DMSO, plasminogen or plasinogen plus DMAG-N-oxide, a membrane impermeant inhibitor of hsp90α. Samples were added to a gelatin zymogram. A representative image taken from three independent experiments is shown. (b) Graphical representation of the plasminogen activation assay. Densitometry results are expressed as the percent decrease in plasmin activation (control set to 100%) and are from three independent experiments. Inhibition of extracellular hsp90α with DMAG-N-oxide results in a 32% decrease in plasmin activation (p < 0.02, two tailed t test).