Table 1.
Top signaling pathways for the 163 differentially expressed probe sets in MCF-7-14 and MDA-MB-231 cells.
| Pathway | Gene mapped to canonical pathways |
|---|---|
| JAK/STAT Signaling | PIK3R1, SOCS2 |
| Xenobiotic Metabolism Signaling | ALDH3B2, MAOB, PIK3R1, UGT1A6 |
| Axonal Guidance Signaling | BMP7, CFL2, CXCL12, PIK3R1, SEMA6D |
| TGF-β Signaling | BMP7, SMURF2 |
| Acute Phase Response Signaling | PIK3R1, SOCS2, TCF3 |
| Leukocyte Extravasation Signaling | CD44, CXCL12, PIK3R1 |
| Neuregulin Signaling | ERRFI1, PIK3R1 |
| IGF-1 Signaling | CYR61, PIK3R1 |
| p53 Signaling | PIK3R1, RPRM |
| LPS/IL-1 Mediated Inhibition of RXR Function | ALDH3B2, MAOB, SLC27A2 |
| Serotonin Receptor Signaling | MAOB |
| Notch Signaling | LFNG |
| Coagulation System | F12 |
| Cell Cycle: G2/M DNA Damage Checkpoint Regulation | RPRM |
| EGF Signaling | PIK3R1 |
| Wnt/β-catenin Signaling | CD44, TCF3 |
Pathway analysis was performed on 163 probe sets (144 unique genes) up- or down-regulated >2-fold in both MCF-7-14 and MDA-MB-231 cells compared with MCF-7 cells (see Additional files 2 and 3) using IPA 5.0. Genes in bold are mapped to multiple top canonical pathways, and genes in bold italics are also mapped on the most significant functional network for the 163 probe sets (see also Figure 5C).