Table 2.
Molecular and phenotypic characterizations of 40 breast cancer cell lines
| Breast cancer cell lines | Breast cancer subtype | Intrinsic subtype | Protein expression | |||
|---|---|---|---|---|---|---|
| ER | PgR | ERBB2 | 3-neg | |||
| SUM185PE | Luminal-type | Luminal | - | - | - | + |
| BT483 | Luminal-type | Luminal | + | - | + | - |
| MDA-MB-134VI | Luminal-type | Luminal | + | - | - | - |
| MDA-MB-175VII | Luminal-type | Luminal | + | - | - | - |
| MDA-MB-415 | Luminal-type | Luminal | + | - | - | - |
| MPE600 | Luminal-type | Luminal | + | - | + | - |
| SUM52PE | Lumina-type | Luminal | + | - | + | - |
| CAMA-1 | Lumina-type | Luminal | + | + | + | - |
| MCF-7 | Luminal-type | Luminal | + | + | - | - |
| ZR75-1 | Luminal-type | Luminal | + | + | + | - |
| SUM44PE | Luminal-type | Luminal | + | + | - | - |
| T47D | Luminal-type | Luminal | + | + | - | - |
| MDA-MB-361 | Luminal-type | Luminal | + | + | ++ | - |
| BT474 | Luminal-type | Luminal | - | + | ++ | - |
| UACC812 | Luminal-type | Luminal | - | + | ++ | - |
| ZR75-30 | Luminal-type | Luminal | + | - | ++ | - |
| OCUB-F | Luminal-type | Luminal | - | - | ++ | - |
| SK-BR-5 | Luminal-type | Luminal | - | - | ++ | - |
| SUM190PT | Luminal-type | nd | - | - | ++ | - |
| SUM225CWN | Luminal-type | nd | - | - | ++ | - |
| MDA-MB-330 | Luminal-type | ERBB2 | + | - | ++ | - |
| MDA-MB-453 | Luminal-type | ERBB2 | - | - | ++ | - |
| SK-BR-3 | Luminal-type | ERBB2 | - | - | ++ | - |
| EVSA-T | Luminal-type | ERBB2 | - | - | ++ | - |
| UACC893 | Luminal-type | ERBB2 | - | - | ++ | - |
| BT20 | Basal-type | Basal-like | - | - | - | + |
| HCC1937 | Basal-type | Basal-like | - | - | - | + |
| MDA-MB-468 | Basal-type | Basal-like | - | - | - | + |
| SUM149PT | Basal-type | Basal-like | - | - | - | + |
| SUM229PE | Basal-type | Basal-like | - | - | - | + |
| BT549 | Basal-type | Normal-like | - | - | - | + |
| Hs578T | Basal-type | Normal-like | - | - | - | + |
| MDA-MB-157 | Basal-type | Normal-like | - | - | - | + |
| MDA-MB-231 | Basal-type | Normal-like | - | - | - | + |
| MDA-MB-436 | Basal-type | Normal-like | - | - | - | + |
| SK-BR-7 | Basal-type | Normal-like | - | - | - | + |
| SUM159PT | Basal-type | Normal-like | - | - | - | + |
| SUM1315MO2 | Basal-type | Normal-like | - | - | - | + |
| SUM102PT | Basal-type | Normal-like | nd | nd | nd | nd |
| MDA-MB-435s | Basal-type | Normal-like | - | - | - | + |
| Total phenotype positives | 14 | 8 | 13 | 16 | ||
Phenotypic characterizations have been reported elsewhere and involved protein expression patterns of the cell lines for the breast cancer subtyping (cytokeratins, ER, PgR and ERBB2) and expression of the intrinsic gene set for the intrinsic subtyping (Hollestelle et al. submitted for publication). Protein expression: +, expressed; ++, over expressed; and -, not detectable; 3-neg, triple-negative.