Table 1.
Patients characteristics and global results for FISH/CISH EGFR GCN analysis and clinical outcome.
| Total Population |
EGFR FISH GCN ≥ 2.6 |
EGFR FISH GCN < 2.6 |
P |
EGFR CISH GCN = 2.12 |
EGFR CISH GCN < 2.12 |
p | |
| Number (%) | 44 | 15 (40) | 22 (60) | 28 (64) | 16 (36) | ||
| Sex (%) | |||||||
| Male | 23 (52) | 10 (67) | 13 (60) | 15 (53) | 9 (56) | ||
| Female | 21 (48) | 5 (33) | 9 (40) | 13 (47) | 7 (44) | ||
| Median age (range) | |||||||
| 66 (39–78) | 66 (39–78) | 66 (39–78) | 65 (39–78) | 66 (40–78) | |||
| Previous lines of Chemotherapy (%) | |||||||
| 1 | 14 (32) | 5 (33) | 8 (36) | 8 (29) | 6 (37) | ||
| > 2 | 30 (68) | 10 (67) | 14 (64) | 20 (71) | 10 (63) | ||
| Response Rate (%) | |||||||
| Complete Remission | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| Partial Remission | 11 (25) | 9 (60) | 2 (9) | 0.002 | 10 (36) | 1 (6) | 0.03 |
| Stable Disease | 12 (27) | 5 (33) | 8 (32) | 10 (36) | 2 (13) | ||
| Progressive Disease | 21 (48) | 1 (7) | 13 (59) | 0.001 | 8 (30) | 13 (81) | 0.01 |
| Not assessable | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| Survival (Months) | |||||||
| Time to Progression | 3.6 | 7.7 | 2.9 | 0.04 | 6.4 | 3.1 | 0.02 |
| Overall Survival | 10.6 | 16 | 9.5 | 10.6 | 10.3 | ||
Only statistically significant p values have been included.