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. Author manuscript; available in PMC: 2011 May 4.
Published in final edited form as: Gut. 2010 Sep 28;59(12):1606–1616. doi: 10.1136/gut.2010.213686

Figure 1.

Figure 1

Bile acid cocktail (BA) induces intracellular acidification that is mediated by nitric oxide. (A) The Delta;pHi after exposure to 0.5 mM BA in the absence or presence of the nitric oxide synthase (NOS) inhibitors NG-nitro-L-arginine methyl ester (L-NAME) and 1400W. (##p<0.01 compared with baseline, **p<0.01, ***p<0.001 compared with 0.5 mM BA). (B) Representative pHi traces in CP-A cells measured by BCECF microfluorimetry. The vertical transparent red box indicates values used to quantify Delta;pHi. The results are mean±SEM from at least three independent experiments. BCECF, 2′,7′-bis(carboxyethyl)-5(6)-carboxyfluorescein.