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. Author manuscript; available in PMC: 2011 May 4.
Published in final edited form as: Gut. 2010 Sep 28;59(12):1606–1616. doi: 10.1136/gut.2010.213686

Figure 4.

Figure 4

Bile acids in combination with acid induce acidification that is mediated by inhibition of the sodium–hydrogen exchanger (NHE). (A) Representative traces of CP-A cells perfused with medium at pH 5.5 with and without 0.5 mM BA with and without NHE inhibitors; dashed line represents extracellular pH (pHe). (B) Recovery (pHi change over time) in CP-A cells after treatment with acid (pH 5.5) and 0.5 mM BA with and without NHE inhibitors. The data represent mean±SEM from more than three independent experiments (*p<0.05, ***p<0.001, compared to pH 5.5 +0.5 mM BA).