Table 2.

Treatment regimens.

(a) IV induction therapy: 600 mg/m2 CTX given on days 1, 2, 4, 6, 8 plus MP given daily for 8 days.

(b) IV pulse therapy with CYX/MP: CTX pulses starting at 800 mg/m2 with dose augmentation in order to obtain a leukopenia of 3000/mm3 and a lynphocitopenia of 800/mm3; every 4 weeks x 18–24 months, every 2 months × 24. 1 g MP given with CTX.

(c) Pulse therapy with CTX at a fixed dose: CTX pulses given at 800–1000 mg/m2 every 4–8 weeks for 12–24 months, given with or without MP.

(d) Combination therapy: IV pulse CTX therapy given concomitantly with beta-interferon or glatiramer acetate in nonresponders.