Table 2. Association tests for three typed SNPs on 2p16.3.
|
Group* |
Genotype no. |
Co-dominant model, p† |
Dominant model |
Statistical power‡ |
|
|---|---|---|---|---|---|
| OR (95% CI)† | p† | ||||
|
rs12994401 (C>T) |
CC/CT/TT |
|
|
|
|
| Controls (n=918) |
376/422/120 |
– |
1 (reference) |
– |
– |
| Glaucoma (n=222) |
101/90/31 |
0.29 |
0.82 (0.61–1.10) |
0.18 |
100% |
| Open-angle |
81/76/29 |
0.37 |
0.89 (0.64–1.22) |
0.46 |
100% |
| High-tension |
76/70/27 |
0.36 |
0.87 (0.63–1.22) |
0.42 |
100% |
| Normal-tension |
5/6/2 |
0.97 |
1.10 (0.36–3.40) |
0.87 |
– |
| Closed-angle |
20/14/2 |
0.13 |
0.51 (0.26–1.01) |
0.054 |
– |
|
rs1533428 (G>A) |
GG/GA/AA |
|
|
|
|
| Controls (n=923) |
355/443/125 |
– |
1 (reference) |
– |
– |
| Glaucoma (n=222) |
96/102/24 |
0.37 |
0.82 (0.61–1.11) |
0.20 |
100% |
| Open-angle |
78/87/19 |
0.46 |
0.85 (0.62–1.18) |
0.33 |
100% |
| High-tension |
74/81/16 |
0.31 |
0.82 (0.59–1.15) |
0.25 |
100% |
| Normal-tension |
4/6/3 |
0.59 |
1.41 (0.43–4.63) |
0.58 |
– |
| Closed-angle |
18/15/5 |
0.59 |
0.71 (0.36–1.37) |
0.30 |
– |
|
rs10202118 (T>C) |
TT/TC/CC |
|
|
|
|
| Controls (n=874) |
333/413/128 |
– |
1 (reference) |
– |
– |
| Glaucoma (n=212) |
88/99/25 |
0.49 |
0.86 (0.63–1.18) |
0.35 |
86% |
| Open-angle |
71/85/20 |
0.58 |
0.90 (0.64–1.26) |
0.53 |
68% |
| High-tension |
68/79/17 |
0.39 |
0.86 (0.61–1.21) |
0.38 |
60% |
| Normal-tension |
3/6/3 |
0.50 |
1.84 (0.49–6.85) |
0.36 |
– |
| Closed-angle | 17/14/5 | 0.66 | 0.73 (0.37–1.44) | 0.36 | – |
*All cases had primary glaucoma of open-angle (including high- and normal-tension subtypes) or closed-angle type. †Odds ratio (OR), 95% confidence interval (CI), and p-values were calculated in comparisons of glaucoma or subtype cases with controls using logistic regression with adjustment for age and gender. ‡Statistical power was calculated for the reported odds ratios [12] using the CaTS method [18], which is applicable only to groups of 100 samples or more.