Table 3. Association tests for 17 typed SNPs on 2p14–2p21.
|
|
Controls |
Glaucoma |
POAG |
Co-dominant, p† |
|
|---|---|---|---|---|---|
| SNP (A>B)/position* | MAF/AA/AB/BB | MAF/AA/AB/BB | MAF/AA/AB/BB | Glaucoma | POAG |
|
rs11685904 (C>T)/48861904 |
0.060/719/96/1 |
0.039/188/16/0 |
0.041/158/14/0 |
0.289 |
0.374 |
|
rs13024367 (C>G)/48899516 |
0.075/717/116/5 |
0.074/180/27/2 |
0.077/149/25/1 |
0.793 |
0.973 |
|
rs17542930 (T>C)/49086284 |
0.187/583/245/40 |
0.198/138/61/11 |
0.212/112/55/10 |
0.893 |
0.599 |
|
rs17483987 (C>T)/49090453 |
0.158/594/204/29 |
0.168/143/47/10 |
0.175/119/41/9 |
0.661 |
0.578 |
|
rs17831941 (A>G)/49484456 |
0.027/641/33/2 |
0.032/192/13/0 |
0.029/162/10/0 |
0.738 |
0.908 |
|
rs13025974 (T>C)/50135149 |
0.242/469/286/52 |
0.274/112/68/21 |
0.272/94/58/17 |
0.124 |
0.224 |
|
rs17039430 (G>A)/50139486 |
0.244/523/345/52 |
0.268/121/83/18 |
0.269/101/67/16 |
0.304 |
0.249 |
|
rs11681755 (A>G)/50457643 |
0.118/635/176/9 |
0.147/149/45/7 |
0.153/121/41/5 |
0.044 |
0.079 |
|
rs727248 (T>C)/51580556 |
0.163/614/240/23 |
0.152/158/52/7 |
0.142/134/415 |
0.386 |
0.360 |
|
rs6545379 (A>G)/54220898 |
0.074/743/114/7 |
0.085/173/31/2 |
0.090/143/27/2 |
0.715 |
0.520 |
|
rs243016 (T>A)/60588713 |
0.141/630/199/20 |
0.138/158/46/6 |
0.136/134/36/6 |
0.882 |
0.580 |
|
rs243052 (C>T)/60590257 |
0.143/649/207/22 |
0.137/159/46/6 |
0.136/135/36/6 |
0.880 |
0.583 |
|
rs12476816 (G>A)/62074097 |
0.308/412/374/80 |
0.343/89/111/20 |
0.341/72/96/14 |
0.104 |
0.053 |
|
rs7581802 (A>C)/62089938 |
0.300/438/397/74 |
0.330/96/107/20 |
0.324/79/92/14 |
0.397 |
0.351 |
|
rs888351 (T>A)/65026329 |
0.103/739/157/15 |
0.109/180/41/4 |
0.104/151/33/3 |
0.844 |
0.991 |
|
rs2098480 (C>T)/65026460 |
0.097/637/129/11 |
0.085/141/20/4 |
0.084/122/18/3 |
0.333 |
0.476 |
| rs737366 (G>T)/65034194 | 0.102/700/151/13 | 0.111/166/38/4 | 0.106/140/31/3 | 0.804 | 0.966 |
*Major allele of each single-nucleotide polymorphism (SNP) is referred to as A and minor allele as B. Chromosome positions of SNPs are based on the NCBI genome build 37.1. Not listed are rs1020049, rs13396706, rs983511, and rs17049908 with minor allele frequency (MAF) <1%. †The p-values for association with susceptibility to glaucoma or primary open-angle glaucoma (POAG) were calculated according to a co-dominant genetic model using logistic regression with adjustment for age and gender.