Table 2.
Overview of the radiolabelling performance in the synthesis of [18F]FPyBrA.
| Radiolabelling performance | Min | Max | Mean±sd | (n) |
|---|---|---|---|---|
| Nitro-precursor (mg) | 3.6 | 9.1 | 5.9±1.2 | (60) |
| Starting [18F]fluoride (MBq) | 85 | 4212 | 780±1021 | (60) |
| Activity in reactor one (%)a | 50 | 100 | 81±10 | (40) |
| Activity in reactor two (%)a | 21 | 51 | 38±9 | (40) |
| Activity in the waste (%)a | 22 | 48 | 34±7 | (40) |
| Unrecovered activity on the QMA catridge (%)a | 1 | 4 | 2±1 | (20) |
| Unrecovered activity on the SepPak catridge (%)a | 1 | 10 | 4±2 | (40) |
| Yield of nucleophilic substitution (% RCY)b | 48 | 89 | 74±11 | (40) |
| Yield of N-Boc-deprotection (% RCY)b | 88 | 100 | 96±4 | (20) |
| Yield of bromoacetylation (% RCY)b | 31 | 78 | 63±10 | (20) |
| Activity recovery during HPLC purification | 60 | 87 | 73±7 | (10) |
| Decay-corrected yielda | 11 | 24 | 17±5 | (10) |
| Non-decay-corrected yield | 7 | 16 | 11±3 | (10) |
a
Decay-corrected based on starting [18F]fluoride.
b
According to TLC.