Table 3.

Microvascular and Microvascular Events During Follow up in Relation to Major Depression at 5 year Assessment

Indicators	No Major Depression N = 2601	Patients with Major Depression N = 158	Unadjusted t-test or chi square	Adjusted§Odds Ratio
Macrovascular or Microvascular Events During Follow-Up (At least 1), N (%)
≥1 Macrovascular Event or Procedure, N (%)	317 (12.2)	31 (19.6)	6.86‡	1.81† 1.18 – 2.80
MI	100 (3.8)	6 (3.8)	0.000	--
Stroke	93 (3.6)	9 (5.7)	1.35	1.75 0.83 – 3.67
Cerebrovascular procedure	16 (0.6)	3 (1.9)	1.97	--
Coronary procedure	182 (7.0)	20 (12.7)	6.27*	1.92* 1.14 – 3.25
PVD procedure	21 (0.8)	0 (0.0)	0.44	--
≥1 Microvascular Event, N (%)	823 (31.6)	47 (29.7)	0.16	0.86 0.30 – 1.24
Amputation	25 (1.0)	2 (1.3)	0.000	--
Retinopathy∥	376 (22.1)	17 (18.9)	0.36	0.69 0.40 – 1.21
Nephropathy¶	517 (37.9)	33 (41.8)	0.32	1.06 0.65 – 1.71
Total Events (Macrovascular and Microvascular Events & Procedures)
Mean (SD) number of macrovascular events or procedures(0-5)	0.16 (0.46)	0.24 (0.52)	2.17*	1.39* 1.02 – 1.88
Mean (SD) number of microvascular events	0.35 (0.55)	0.33 (0.54)	0.53	0.88 0.64 – 1.21

^§adjusted for non response probability and PHQ depression score groups at baseline assessment

^∥development of retinopathy in patients without previous evidence of retinopathy (eligible patients N = 1787)

^¶development of nephropathy in patients without previous evidence of nephropathy (eligible patients N = 1442)

^*p < .05

^†p < .01

^‡p < .001