. 2009 Dec 2;10:78. doi: 10.1186/1471-2156-10-78

Table 4.

Type I error of the uncorrected, GC and RGC-corrected tests when the markers are linked to the disease with probability 2% (nominal level is 0.05, K = 200, a = (500, 1500), b = (1500, 500), F = 0.02, f₂, f₁, f₀are the penetrances for AA, Aa, aa.)

(f₀, f₁, f₂)	MAF	Method	T₀	T_1/2	T₁
(0.01, 0.02, 0.02)	p = 0.2	Uncorrected	0.470	0.673	0.657	0.631
		GC	0.021	0.041	0.055	0.035
		RGC	0.064	0.051	0.047	0.058
(0.01, 0.015, 0.02)		Uncorrected	0.474	0.679	0.656	0.637
		GC	0.018	0.042	0.056	0.034
		RGC	0.056	0.052	0.051	0.054
(0.01, 0.01, 0.02)		Uncorrected	0.473	0.669	0.653	0.630
		GC	0.022	0.040	0.054	0.039
		RGC	0.063	0.052	0.053	0.055

(0.01, 0.02, 0.02)	p = 0.45	Uncorrected	0.592	0.668	0.615	0.630
		GC	0.098	0.046	0.034	0.062
		RGC	0.054	0.051	0.046	0.049
(0.01, 0.015, 0.02)		Uncorrected	0.608	0.675	0.619	0.638
		GC	0.105	0.045	0.033	0.060
		RGC	0.053	0.052	0.053	0.050
(0.01, 0.01, 0.02)		Uncorrected	0.598	0.670	0.620	0.631
		GC	0.103	0.045	0.034	0.061
		RGC	0.049	0.051	0.054	0.048